Confirming H. pylori eradication
accurately is more important
than ever1,2
American College of Gastroenterology reports declining eradication rates1
- Evidence shows that eradication therapy can fail in 1 out of 4 patients2
Helicobacter pylori
References: 1. Chey WD, Wong BCY; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825. 2. Vakil N, Fendrick AM. How to test for Helicobacter pylori in 2005. Cleve Clin J Med. 2005;72(suppl 2):S8-S13.
BreathTek UBT for H. pylori has excellent sensitivity (95.5%)
and specificity (96.0%) when confirming eradication1
-
-
-
- Stool
(antigen test)
- 93%*
- 93%*
-
- Serology†
(ELISA)
- N/A†
- N/A†
-
Both ACG and AGA guidelines recommend the UBT method as an appropriate choice for initial diagnosis and confirmation of eradication4,5
False negative test results may be caused by
- Ingestion of antimicrobials, proton pump inhibitors, and bismuth preparations within 2 weeks prior to administering BreathTek UBT
- Premature POST-DOSE breath collection time for a patient with a marginally positive BreathTek UBT result
- Post-treatment assessment with the BreathTek UBT less than 4 weeks after completion of treatment for the eradication of H. pylori
A false positive test may occur due to urease associated with other gastric spiral organisms observed in humans, such as Helicobacter heilmannii and Achlorhydria.
References:
1. Package Insert for BreathTek UBT. Otsuka America Pharmaceutical, Inc; 2012.
2. Vaira D, Vakil N. Blood, urine, stool, breath, money, and Helicobacter pylori. Gut. 2001;48(3):287-289.
3. Maconi G, Vago L, Galletta G, et al. Is routine histological evaluation an accurate test for Helicobacter pylori infection? Aliment Pharmacol Ther. 1999;13(3):327-331.
4. Chey WD, Wong BCY; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825.
5. Talley NJ, Vakil NB, Moayyedi P. American Gastroenterological Association technical review on the evaluation of dyspepsia. Gastroenterology. 2005;129(5):1756-1780.
BreathTek UBT makes H. pylori detection convenient
NO SPECIAL TRAINING NEEDED
MINIMAL STAFF TIME NEEDED
NO DEDICATED
TESTING ROOM NEEDED
- Send samples to a local lab or perform the analysis in your office
- Specific instruments are available so both administration and analysis can be performed in-office
The UBT method is more convenient compared with invasive H. pylori tests1,2*
- The UBT method is the first-choice noninvasive test because of its high accuracy, convenience, and availability2
- By simply measuring the ratio of 13CO2 to 12CO2 in the patient's breath samples, BreathTek UBT accurately detects H. pylori-associated urease (95.5% sensitivity and 96.0% specificity to confirm eradication)1,2
BreathTek UBT contains phenylalanine, a component of aspartame; use with caution in diabetic or PKU patients
References: 1. Gisbert JP, Pajares JM. Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection –
a critical review. Aliment Pharmacol Ther. 2004;20(10):1001-1017. 2. Mégraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing.
Clin Microbiol Rev. 2007;20(2):280-322.