BreathTek® UBT for H. pylori
may be administered to
patients currently taking PPIs
- It is still recommended that antimicrobials, PPIs, or bismuth preparations not be taken within 2 weeks prior to administering the BreathTek UBT1
- If patients currently taking PPIs test positive for H. pylori, it is considered positive and eradication therapy can be started immediately1; if the test is negative, it may be a false negative and results should be confirmed with a second breath test 2 weeks after discontinuing PPIs1
Reference: 1. Package Insert for BreathTek UBT. Otsuka America Pharmaceutical, Inc; 2013.
Confirming H. pylori eradication
accurately is more important
American College of Gastroenterology reports declining eradication rates1
- Evidence shows that eradication therapy can fail in 1 out of 4 patients2
References: 1. Chey WD, Wong BCY; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825. 2. Vakil N, Fendrick AM. How to test for Helicobacter pylori in 2005. Cleve Clin J Med. 2005;72(suppl 2):S8-S13.
BreathTek UBT for H. pylori has excellent sensitivity (95.5%)
and specificity (96.0%) when confirming eradication1
Both ACG and AGA guidelines recommend the UBT method as an appropriate choice for initial diagnosis and confirmation of eradication4,5
False negative test results may be caused by
- Ingestion of antimicrobials, proton pump inhibitors, and bismuth preparations within 2 weeks prior to administering BreathTek UBT
- Premature POST-DOSE breath collection time for a patient with a marginally positive BreathTek UBT result
- Post-treatment assessment with the BreathTek UBT less than 4 weeks after completion of treatment for the eradication of H. pylori
A false positive test may occur due to urease associated with other gastric spiral organisms observed in humans, such as Helicobacter heilmannii and Achlorhydria.
1. Package Insert for BreathTek UBT. Otsuka America Pharmaceutical, Inc; 2012.
2. Vaira D, Vakil N. Blood, urine, stool, breath, money, and Helicobacter pylori. Gut. 2001;48(3):287-289.
3. Maconi G, Vago L, Galletta G, et al. Is routine histological evaluation an accurate test for Helicobacter pylori infection? Aliment Pharmacol Ther. 1999;13(3):327-331.
4. Chey WD, Wong BCY; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808-1825.
5. Talley NJ, Vakil NB, Moayyedi P. American Gastroenterological Association technical review on the evaluation of dyspepsia. Gastroenterology. 2005;129(5):1756-1780.
BreathTek UBT makes H. pylori detection convenient
NO SPECIAL TRAINING NEEDED
MINIMAL STAFF TIME NEEDED
TESTING ROOM NEEDED
- Send samples to a local lab or perform the analysis in your office
- Specific instruments are available so both administration and analysis can be performed in-office
The UBT method is more convenient compared with invasive H. pylori tests1,2*
- The UBT method is the first-choice noninvasive test because of its high accuracy, convenience, and availability2
- By simply measuring the ratio of 13CO2 to 12CO2 in the patient's breath samples, BreathTek UBT accurately detects H. pylori-associated urease (95.5% sensitivity and 96.0% specificity to confirm eradication)1,2
BreathTek UBT contains phenylalanine, a component of aspartame; use with caution in diabetic or PKU patients
References: 1. Gisbert JP, Pajares JM. Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection –
a critical review. Aliment Pharmacol Ther. 2004;20(10):1001-1017. 2. Mégraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing.
Clin Microbiol Rev. 2007;20(2):280-322.